General Objective

  • To assess the outcome of different intervention (lifestyle, metformin and glibenclamide) models to prevent diabetes among high risk group in Bangladesh.

Specific Objectives

  • To observe the rate of conversion of IGT to diabetes.
  • To evaluate the impact of intervention only with lifestyle modification including prescribe dietary and exercise advice.
  • To note the usefulness of an insulin sensitizer (Metformin 500 mg ) in this population
  • To note the usefulness of an insulin secretagogue (Glibenclamide 1mg ) in this population
  • To register the benefits of combining lifestyle modification and Metformin
  • To register the benefits of combining lifestyle modification and Glibenclamide
  • To observe the relation of IGT and depression
  • To measure the cost effectiveness & different models